| 主权项 |
1. A compound represented by formula I:or a pharmaceutically acceptable salt thereof, wherein
Rb is selected from the group consisting of H, halogen, hydroxyl, cyano and C1-C6 alkyl; R1 is H or C1-C6 alkyl; R2 is H or C1-C6 alkyl; R3 is selected from the group consisting of H, C1-C6alkyl, —OH, C1-C6alkoxy, —OC(O)—C1-C6 alkyl and —OC(O)-phenyl (optionally substituted by one, two or three substituents independently selected from the group consisting of halogen, hydroxyl, C1-C6alkyl, and C1-C6alkoxy); R4 is H or C1-C6 alkyl; X is selected from the group consisting of:
(i) hydrogen;(ii) —C1-6alkylene-C3-6cycloalkyl;(iii) —C1-6alkylene-heterocyclyl including from 3 to 6 ring atoms wherein 1, 2, or 3 of the ring atoms are independently selected from the group consisting of N, NH, N(C1-C3 alkyl), O, and S; wherein the heterocyclyl is optionally substituted by one, two or three substituents independently selected from the group consisting of halogen, hydroxyl, C1-C6alkyl, and C1-C6alkoxy);(iv) —C1-6alkylene-C(O)-heterocyclyl including from 3 to 6 ring atoms wherein 1, 2, or 3 of the ring atoms are independently selected from the group consisting of N, NH, N(C1-C3 alkyl), O, and S; wherein the heterocyclyl is optionally substituted by one, two or three substituents independently selected from the group consisting of halogen, hydroxyl, C1-C6alkyl, and C1-C6alkoxy);(v) —C1-6alkylene-heteroaryl including from 5 to 6 ring atoms wherein 1, 2, or 3 of the ring atoms are independently selected from the group consisting of N, NH, N(C1-C3 alkyl), O, and S; wherein the heteroaryl is optionally substituted by one, two or three substituents independently selected from the group consisting of halogen, hydroxyl, C1-C6alkyl, and C1-C6alkoxy;(vi) branched unsubstituted C3-C6 alkyl; and(vii) branched C3-C6 alkyl substituted with —C(O)NH2 on one carbon and —OH on another carbon; and wherein the —NH2 group attached to the carbon adjacent to —CH(R3)(R4) is optionally substituted with a substituent selected from —C(O)OR31 and —C(O)R32, wherein: R31 is selected from the group consisting of: C1-C6 alkyl; C1-C6 haloalkyl; C2-C6 alkenyl; C2-C6 alkynyl; C3-C10 cycloalkyl, wherein the C3-C10 cycloalkyl is optionally substituted with from 1-3 independently selected C1-C3 alkyl; —CH2—C3-C10 cycloalkyl wherein the C3-C10 cycloalkyl is optionally substituted with from 1-3 independently selected C1-C3 alkyl; —CH2-phenyl, wherein the phenyl is optionally substituted with from 1-2 substituents independently selected from C1-C3 alkyl; C1-C3 haloalkyl; C1-C3 alkoxy; C1-C3 haloalkoxy; nitro; halo; SO2Me, cyano; and —OC(O)CH3; and —CH2— pyridyl; and R32 is selected from the group consisting of: H; C1-C6 alkyl; C1-C6 haloalkyl; phenyl, wherein the phenyl is optionally substituted with from 1-2 substituents independently selected from C1-C3 alkyl; C1-C3 haloalkyl; C1-C3 alkoxy; C1-C3 haloalkoxy; nitro; halo; SO2Me, cyano; and —OC(O)CH3; and pyridyl. |
