| 摘要 |
To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases.;A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof:;;wherein the respective substituents are defined in detail in the specification, and R1 is a C1-6 alkyl group or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or the like, the ring A is C3-11 cycloalkane or the like, L1 is a C1-6 alkylene group or the like, and R4 is NRaRb or the like. |
| 主权项 |
1: A compound represented by formula (I):a tautomer thereof, a pharmaceutically acceptable salt thereof or a solvate thereof,wherein;
A is C3-11 cycloalkane, or a 4 to 7-membered non-aromatic heterocyclic ring, R1 is a hydrogen atom, a C3-6 cycloalkyl group, a 4 to 7-membered non-aromatic heterocyclic group, a C1-6 haloalkyl group, or a C1-6 alkyl group, wherein the C1-6 alkyl group is optionally substituted with a hydroxy group, a cyano group, a C1-6 alkoxy group, a C1-6 alkylthio group, a C1-6 alkylsulfonyl group, a carboxy group, a carbamoyl group, a mono-C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, a C3-6 cycloalkyl group or a 4 to 7-membered non-aromatic heterocyclic group, each of R2 and R3 is independently a hydrogen atom, or a C1-6 alkyl group, L1 is a single bond, a C1-6 alkylene group, or a C1-6 haloalkylene group, R4 is a hydrogen atom, a halogen atom, NRaRb, NRcS(═O)2Rd, ORe, formula (II)-1, or formula (II)-2: each of Ra and Re is independently a hydrogen atom, a C1-6 alkyl group, a cyano-substituted C1-6 alkyl group, a C1-6 alkylsulfonyl-substituted C1-6 alkyl group, a C1-6 haloalkyl group, a C3-6 cycloalkyl group, a cyano-substituted C3-6 cycloalkyl group, or a C1-6 haloalkyl-substituted C3-6 cycloalkyl group, each of Rb and Rc is independently a hydrogen atom, a C1-6 alkyl group, or a C1-6 haloalkyl group, Rd is a C1-6 alkyl group, a cyano-substituted C1-6 alkyl group, a C1-6 haloalkyl group, a C3-6 cycloalkyl group, a cyano-substituted C3-6 cycloalkyl group, or a C1-6 haloalkyl-substituted C3-6 cycloalkyl group, Rf is a halogen atom, a hydroxy group, a cyano group, a C1-6 alkyl group, or a C1-6 haloalkyl group, Rg is a hydrogen atom, a C1-6 alkyl group, a cyano-substituted C1-6 alkyl group, or a C1-6 haloalkyl group, each of Xa and Xb is independently S(═O)2, C═O, or CH, n is 0, 1 or 2, wherein when n is 2, each Rf may be identical with or different from each other, and m is 0, 1 or 2. |
