发明名称 PIPERIDINYLCARBAZOLES
摘要 The present invention provides compounds of Formula (I) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (I) wherein R3, R4, X and Y have the meaning given in claim 1.;
申请公布号 US2015368226(A1) 申请公布日期 2015.12.24
申请号 US201314760336 申请日期 2013.12.27
申请人 MERCK PATENT GMBH 发明人 ROUTIER Julie;SPANGENBERG Thomas
分类号 C07D401/04;A61K31/454;A61K31/4545;C07D471/04 主分类号 C07D401/04
代理机构 代理人
主权项 1. A compound of formula I: wherein Y is a group selected from R1 denotes H or F, R2 denotes OH or F, X denotes CH or N, R3 and R4 independently of one another denote H, Hal or OA, CHal3 Hal is F, Cl, Br or I, A denotes H or Alk, Alk is a branched or linear alkyl group having 1 to 8 carbon atoms or cycloalkyl having 3 to 6 carbon atoms, wherein 1 to 7 H-atoms may be independently replaced by Hal, OR, COOR, CN, NR2, phenyl, linear or branched alkyl having 1, 2 or 3 C atoms, cycloalkyl having 3 to 6 carbon atoms and/or wherein 1 to 3 CH2-groups may be replaced by O, —NRCO—, —CO—, —COO—, —CONR, —NR— or S, or cycloalkyl having 3 to 6 carbon atoms, R is H or is a branched or linear alkyl group having 1 to 8 carbon atoms and pharmaceutically acceptable salts esters and N-oxides thereof.
地址 Darmstadt DE