PHARMACEUTICAL COMPOSITIONS INCORPORATING LOW-DOSE DRUGS

摘要

The present invention relates to novel pharmaceutical compositions in powder or granule form which comprise a low-dose drug attached to a water-soluble carrier, such as by adhesion or adsorption. The compositions further comprise an oily liquid which facilitates the attachment of the active ingredient to the carrier particles. Moreover, the invention provides methods for preparing such powders or granules, and compressed tablets incorporating them.

主权项

1. A pharmaceutical powder or granule composition for oral use, comprising
(a) an active ingredient at a level of not more than about 10 wt.-%; (b) a water-soluble, pharmaceutically acceptable carrier; and (c) an oily excipient which is liquid at room temperature; whereinthe weight ratio of the water-soluble carrier to the oily excipient is at least about 5 to 1.