| 发明名称 |
COMPOSITION WITH HIGH ANTIMICROBIAL ACTIVITY AND LOW TOXICITY |
| 摘要 |
Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections. |
| 申请公布号 |
US2015366193(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201514693601 |
申请日期 |
2015.04.22 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ;Amicrobe, Inc. |
发明人 |
Bevilacqua Michael P.;Benitez Diego;Deming Timothy J.;Hanson Jarrod A.;Koziol Lucas |
| 分类号 |
A01N37/18;A61K38/16 |
主分类号 |
A01N37/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antimicrobial composition comprising:
at least one species of synthetic copolypeptide of at least forty amino acid residues comprising:
at least one hydrophilic segment containing at least five contiguous cationic amino acid residues; andat least one hydrophobic segment containing at least five contiguous hydrophobic amino acid residues;wherein the hydrophilic segment contains a larger number of amino acid residues than the hydrophobic segment; and water; wherein the composition of said copolypeptide in aqueous media forms
structures; and wherein the composition inhibits or kills microbes. |
| 地址 |
Oakland CA US |
