METHODS AND SYSTEMS FOR TOXIN DELIVERY TO THE NASAL CAVITY

摘要

Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

主权项

1. A method for treating a nasal condition in a patient, said method comprising:
inserting an applicator tip of an apparatus through a nostril of the patient and into a nasal cavity of the patient, wherein the applicator tip comprises an inner expandable member and an outer expandable member extending around the inner expandable member, wherein the inner expandable member is expanded in the nasal cavity thereby causing the outer expandable member to expand and contact a wall of the nasal cavity, and wherein a toxin is delivered from the expanded outer expandable member to target cells in the wall of the nasal cavity.