PRESCRIPTION DECISION SUPPORT SYSTEM AND METHOD USING COMPREHENSIVE MULTIPLEX DRUG MONITORING

摘要

A decision support system and method for optimizing medication dosages includes comprehensive patient databases correlating medications and exposure values across data models having pharmacokinetic and pharmacodynamic dimensions. The system determines distinctions between expected and detected medications and exposure values for a patient, and further distinguishes between non-compliant patients from compliant patients having high metabolizing characteristics with respect to certain expected but undetected medications. The system links to and reconciles the patient medical record accordingly. Graphical user interfaces display recommended dosages and projected exposure ranges for the expected and detected medications. In an embodiment, the interface presents certain alternative treatment options determined as being available with respect to the expected but undetected medications. The user in an embodiment may manipulate or select respective nominal dosage values or alternative treatment options, wherein projected exposure values are dynamically calculated and displayed for each of the medications.

主权项

1. A decision support method for optimizing medication dosages, the method comprising:
identifying one or more expected medications and desired exposure values for a patient from at least an associated patient medical record; determining one or more actual medications and exposure values for the patient from at least multiplex assay results associated with the patient; with respect to each of one or more distinctions between the expected and actual medications and exposure values, determining whether the respective distinction is based on non-compliance by the patient or compliance by the patient further in view of metabolizing characteristics of the patient, and accuracy of the medical record; graphically generating a user interactive interface on a display unit comprising dosage values for each of the one or more identified expected medications and actual medications, and associated projected exposure ranges for each of the displayed medications; enabling user manipulation of respective dosage values for any one or more of the medications; and dynamically calculating and displaying projected exposure values for each of the one or more medications based on the one or more user manipulated dosage values.