| 发明名称 |
FORMULATIONS OF GUANYLATE CYCLASE C AGONISTS AND METHODS OF USE |
| 摘要 |
The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative. |
| 申请公布号 |
US2015366935(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201514845644 |
申请日期 |
2015.09.04 |
| 申请人 |
SYNERGY PHARMACEUTICALS INC. |
发明人 |
COMISKEY Stephen;FENG Rong;FOSS John;SHAILUBHAI Kunwar |
| 分类号 |
A61K38/12;A61K45/06 |
主分类号 |
A61K38/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating chronic constipation in a patient comprising orally administering to said patient a composition comprising a per unit dose of 3 mg or 6 mg of a peptide consisting of SEQ ID NO:1 wherein the peptide is a [4,12; 7,15] bicycle and one or more pharmaceutically acceptable excipients. |
| 地址 |
NEW YORK NY US |
