发明名称 |
Fluorescent solid lipid nanoparticles composition and preparation thereof |
摘要 |
The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and /or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield. |
申请公布号 |
AU2014273118(A1) |
申请公布日期 |
2015.12.24 |
申请号 |
AU20140273118 |
申请日期 |
2014.05.28 |
申请人 |
BRACCO IMAGING SPA |
发明人 |
GHIANI, SIMONA;MAIOCCHI, ALESSANDRO;CAMINITI, LARA;MIRAGOLI, LUIGI |
分类号 |
A61K49/00;A61K9/107;A61K9/51 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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