| 发明名称 |
MDL-1 LIGAND |
| 摘要 |
The invention provides methods for modulation interactions between MDL-1 and its binding partner, Gal9. Also provided are methods to screen for modulators of MDL-1/Gal9 interaction. |
| 申请公布号 |
US2015368344(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201514744706 |
申请日期 |
2015.06.19 |
| 申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
Joyce-Shaikh Barbara;Wilson Douglas C.;Cua Daniel J.;LaFace Drake M.;Beaumont Maribel;Cherwinski Holly;Hsieh Mark;Benchaar Sabrina;Phillips Joseph H. |
| 分类号 |
C07K16/28;C07K14/705;G01N33/50 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of modulating an interaction between a lectin-like molecule expressed on myeloid cells, and a lectin which binds to a receptor expressed by a T cell, the method comprising:
a) providing a compound that is capable of binding to lectin-like molecule at a binding site of the lectin; and b) presenting the compound of step (i) to lectin-like molecule and the lectin and thereby modulating the interaction between the first and second lectin. |
| 地址 |
Rahway NJ US |
