INSULIN SECRETING POLYPEPTIDES

摘要

This document provides methods and materials related to insulin secreting polypeptides. For example, polypeptides having the ability to induce insulin secretion and methods and materials for using use such polypeptides to induce insulin secretion and to treat diabetes are provided.

主权项

1. A polypeptide selected from the group consisting of:
(a) a polypeptide from 15 to 21 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:1 or the sequence set forth in SEQ ID NO:1 with no more than four amino acid additions, subtractions, or substitutions; (b) a polypeptide from 45 to 55 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:2 or the sequence set forth in SEQ ID NO:2 with no more than four amino acid additions, subtractions, or substitutions; (c) a polypeptide from 45 to 55 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:3 or the sequence set forth in SEQ ID NO:3 with no more than four amino acid additions, subtractions, or substitutions; (d) a polypeptide from 45 to 55 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:4 or the sequence set forth in SEQ ID NO:4 with no more than four amino acid additions, subtractions, or substitutions; (e) a polypeptide from 45 to 55 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:5 or the sequence set forth in SEQ ID NO:5 with no more than four amino acid additions, subtractions, or substitutions; (f) a polypeptide from 45 to 55 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:6 or the sequence set forth in SEQ ID NO:6 with no more than four amino acid additions, subtractions, or substitutions; (g) a polypeptide from 40 to 50 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:7 or the sequence set forth in SEQ ID NO:7 with no more than four amino acid additions, subtractions, or substitutions; (h) a polypeptide from 40 to 50 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:8 or the sequence set forth in SEQ ID NO:8 with no more than four amino acid additions, subtractions, or substitutions; (i) a polypeptide from 35 to 45 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:9 or the sequence set forth in SEQ ID NO:9 with no more than four amino acid additions, subtractions, or substitutions; (j) a polypeptide from 35 to 45 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:10 or the sequence set forth in SEQ ID NO:10 with no more than four amino acid additions, subtractions, or substitutions; (k) a polypeptide from 50 to 60 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:11 or the sequence set forth in SEQ ID NO:11 with no more than four amino acid additions, subtractions, or substitutions; (l) a polypeptide from 50 to 60 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:12 or the sequence set forth in SEQ ID NO:12 with no more than four amino acid additions, subtractions, or substitutions; (m) a polypeptide from 45 to 55 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:13 or the sequence set forth in SEQ ID NO:13 with no more than four amino acid additions, subtractions, or substitutions; (n) a polypeptide from 45 to 55 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:14 or the sequence set forth in SEQ ID NO:14 with no more than four amino acid additions, subtractions, or substitutions; (o) a polypeptide from 50 to 60 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:15 or the sequence set forth in SEQ ID NO:15 with no more than four amino acid additions, subtractions, or substitutions; (p) a polypeptide from 50 to 60 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:16 or the sequence set forth in SEQ ID NO:16 with no more than four amino acid additions, subtractions, or substitutions; (q) a polypeptide from 50 to 65 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:17 or the sequence set forth in SEQ ID NO:17 with no more than four amino acid additions, subtractions, or substitutions; and (r) a polypeptide from 50 to 65 amino acid residues in length, wherein said polypeptide comprises the sequence set forth in SEQ ID NO:18 or the sequence set forth in SEQ ID NO:18 with no more than four amino acid additions, subtractions, or substitutions.