主权项 |
1. A compound represented by Formula I: Wherein R1 is selected from the group consisting of —(CRa2)nCOOR11, —(CRa2)nNR5SO2R6, —(CRa2)nSO2NR5R6, —(CRa2)nC(O)NRcSO2N(Rc)2, —(CRa2)nC(O)R5, —(CRa2)nCONR5R6, —(CRa2)nS(O)Rc, —(CRa2)nS(O)2Rc, and a nitrogen containing 5-membered heterocyclyl, heteroaryl and heterocyclenyl ring selected from the group consisting of tetrazolyl, oxadiazolyl, oxadiazolone, dihydro-oxadiazolyl, triazolyl, dihydro-triazolyl, dihydro-triazolone, and pyrrolidinyl, wherein the 5-membered ring can be optionally substituted with ORc, SRc NH2, nitro, CN, amide, COOR11, C1-C6alkyl, C1-C6haloalkyl, C1-C6haloalkyloxy, C1-C6hydroxyalkyl, C1-C6alkenyl, C1-C6alkyl-C(═O)O—, C1-C6alkyl-C(═O)—, C1-C6alkynyl, halo group, hydroxyalkoxy, —SO2NRcRc, —NRcSO2Rc, C1-C6alkylsulfonyl, C1-C6alkylamino or di(C1-C6)alkylamino; R2 is selected from the group consisting of phenyl, pyridyl, or —W—(CRaR9)tR7, wherein W is NRc or O, wherein the phenyl or pyridyl is optionally substituted with R12 selected from the group consisting of halo, CN, —(CRa2)zCOOR10, haloC1-C6alkyl, C1-C6alkyl, —ORc, —(CRa2)zaryl, —(CRa2)zheterocyclic, —(CRa2)zcyclenyl, and —(CRa2)zheterocyclenyl, wherein the alkyl, aryl, heterocyclic, cyclenyl and heterocyclenyl of R12 can be optionally substituted with OH, NH2, nitro, CN, CON(Rc)2, —(CRa2)zCOOR10, C1-C6alkoxy, C1-C6alkyl, C1-C6haloalkyl, Cr C6haloalkyloxy, C1-C6hydroxyalkyl, C2-C6alkenyl, C1-C6alkyl-C(═O)O—, C1-C6alkyl-C(═O)—, C2-C6alkynyl, halo group, hydroxyalkoxy, —NRcSO2Rc, C1-C6alkylamino or di(C1-C6)alkylamino; R4 is selected from the group consisting of C1-C6alkyl, —(CRa2)maryl, —(CRa2)mheteroaryl, —(CRa2)mheterocyclic, —(CRa2)mC5-C6cycloalkyl, —(CRa2)mcyclohexenyl and —(CRa2)mheterocyclenyl, wherein the alkyl, aryl, heteroaryl, heterocyclic, cycloalkyl, cyclohexenyl, and heterocyclenyl can be optionally substituted with NH2, nitro, CN, CON(Rc)2, COOR10, C1-C6alkoxy, C1-C6alkyl, C3-C6cycloalkyl, haloC2-C6alkenyl, C2-C6alkenyl, C2-C6alkenoxy, C1-C6haloalkyl, C1-C6haloalkyloxy, C1-C6hydroxyalkyl, C1-C6alkyl-C(═O)O—, C1-C6alkyl-C(═O)—, C2-C6alkynyl, halo group, hydroxyalkoxy, —SO2NRcRc, —NRcSO2Rc, C1-C6alkylsulfonyl, C1-C6alkylamino or di(C1-C6)alkylamino; R5 is independently selected from the group consisting of H, C1-C6alkyl, —C0-C6alkyl-C3-C8cycloalkyl, —C0-C6alkyl-heteroaryl, —C0-C6alkyl-aryl, and —C0-C6alkylheterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, aryl, and heterocyclic can be optionally substituted with C2-C3alkenyl, C3-C6cycloalkyl, C1-C3alkoxy, OH, halo, NH2, C1-C3alkylamino, C1-C3dialkylamino or COOR11; R6 is independently selected from the group consisting of H, C1-C6alkyl, —C0-C6alkyl-C3-C8cycloalkyl, —C0-C6alkyl-heteroaryl, —C0-C6alkyl-aryl, and —C0-C6alkylheterocyclic, wherein the alkyl, cycloalkyl, heteroaryl, aryl, and heterocyclic can be optionally substituted with C2-C3alkenyl, C3-C6cycloalkyl, C1-C3alkoxy, OH, halo, NH2, C1-C3alkylamino, C1-C3dialkylamino or COOR11; R7 is selected from the group consisting of H, C1-C6alkyl, C2-C6alkenyl, C3-C8cycloalkyl, aryl, heteroaryl, and heterocyclic, wherein the alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclic can be optionally substituted with halo, nitro, CN, C1-C6haloalkyl, Cr C6haloalkyloxy, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkyl, —C0-C6alkyl-C3-C8cycloalkyl, —C0-C6alkyl-heteroaryl, —C0-C6alkyl-aryl, —C0-C6alkylheterocyclic, —C0-C6alkylheterocyclenyl, —C0-C6alkylcyclenyl, —(CRa2)zNR5R6, —(CRa2)zNR5SO2R6, —(CRa2)zSO2NR5R6, —(CRa2)zC(O)R5, —(CRa2)zC(O)OR10, —(CRa2)zCONR5R6, —(CRa2)zCONR5OR6, —(CRa2)zNR5C(O)R6, —(CRa2)zOR5, —(CRa2)zS(O)Rc, and —(CRa2)zS(O)2Rc; R9 is independently selected from the group consisting of H, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, aryl, heteroaryl, and heterocyclic, wherein the alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclic can be optionally substituted with —C0-C6alkylORc, C0-C6alkylN(Rc)2, COOR10, nitro, CN, C1-C6alkyl, C1-C6haloalkyl, C1-C6haloalkyloxy, C1-C6hydroxyalkyl, C2-C6alkenyl, C1-C6alkyl-C(═O)O—, C1-C6alkyl-C(═O)—, C2-C6alkynyl, halo group, hydroxyalkoxy, —SO2NRcRc, —NRcSO2Rc, C1-C6alkylsulfonyl, heterocylic, or C(O)NHRc; R10 is independently selected from the group consisting of C1-C6alkyl, —(CRc2)zC3-C8cycloalkyl, —(CRc2)z-heteroaryl, —(CRc2)z-aryl, and —(CRc2)z-heterocyclic, wherein the heteroaryl, aryl, heterocyclic, cycloalkyl and alkyl can be optionally substituted with C1-C6alkyl, OH, halo, or haloC1-C6alkyl; R11 is independently selected from the group consisting of H, C1-C6alkyl, —(CRc2)zC3-C8cycloalkyl, —(CRc2)zheteroaryl, —(CRc2)zaryl, and —(CRc2)zheterocyclic wherein the heteroaryl, aryl, heterocyclic, cycloalkyl and alkyl can be optionally substituted with C1-C6alkyl, OH, halo, or haloC1-C6alkyl; Ra is independently H, ORc, NH2, halo, C1-C3alkyl, or C2-C3alkenyl, said alkyl or alkenyl is optionally substituted with OH, C1-C4alkoxy, NH2, halo, haloC1-C4alkyl, C3-C6cycloalkyl, or C2-C4alkenyl; Rc is independently H or C1-C3alkyl optionally substituted with C2-C3alkenyl, C3-C6cycloalkyl, C1-C3alkoxy, OH, halo, NH2, C1-C3alkylamino, or C1-C3dialkylamino; n is independently 0, 1, 2 or 3; m is independently 0, 1 or 2; t is independently 0, 1, or 2; z is independently 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof. |