| 发明名称 |
METHODS FOR EXPANSION OR DEPLETION OF T-REGULATORY CELLS |
| 摘要 |
The invention features methods of producing compositions enriched in Tregs and methods for treating immunological disorders using these compositions. The invention also features methods for producing compositions enriched in lymphocytes and depleted of Tregs and the use of these compositions in the treatment of proliferative disorders. |
| 申请公布号 |
US2015366909(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201414764325 |
申请日期 |
2014.02.06 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
FAUSTMAN Denise L. |
| 分类号 |
A61K35/17;C07K16/28;C12N5/0783 |
主分类号 |
A61K35/17 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for producing a composition enriched in CD4+CD25hi T regulatory cells (Tregs) comprising contacting in vitro a population of human cells comprising T-lymphocytes obtained from a human blood or bone marrow sample from a patient with a tumor necrosis factor receptor 2 (TNFR2) agonist or an NF-κB activator, thereby producing said composition enriched in Tregs, wherein said Tregs comprise at least 60% of the cells in said composition. |
| 地址 |
Boston MA US |
