Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers

摘要

GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS Modified glucagon peptides are disclosed having improved solubility and/or half-life while 5 retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:23, or both to further enhance the solubility of the glucagon agonist analogs.