| 摘要 |
PROBLEM TO BE SOLVED: To solve the problem that compounds of a formula I as defined in the specifications may exhibit very low bulk density, poor solubility and/or poor flow characteristics, which increases the difficulty in formulating and/or manufacturing a dosage formulation containing the active compound.SOLUTION: The present disclosure relates to compositions and pharmaceutical formulations comprising at least one active pharmaceutical ingredient selected from nitrocatechol derivatives of a formula I as defined in the specifications and their salts, esters, hydrates, solvates and other derivatives, and methods of making the compositions and pharmaceutical formulations. |
