发明名称 MICRO-RNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER-RELATED DISEASES
摘要 PROBLEM TO BE SOLVED: To provide a method for diagnosing whether a subject has, is at risk for developing, or has reduced survival prognosis for, a colon cancer-related disease, as well as a method for inhibiting tumorigenesis in a subject having colon cancer.SOLUTION: A diagnosing method comprises measuring the level of at least one miR gene product, where an alteration in the level of the miR gene product in a test sample, relative to the level of a corresponding miR gene product in a control sample, is indicative of the subject either having or being at risk for developing the colon cancer-related disease. Also provided is a method for inhibiting tumorigenesis which comprises altering the amount of miR gene product expressed in the cancer cells.
申请公布号 JP2015231376(A) 申请公布日期 2015.12.24
申请号 JP20150136948 申请日期 2015.07.08
申请人 OHIO STATE UNIV RESEARCH FOUNDATION:THE;USA GOVERNMENT 发明人 CROCE CARLO M;HARRIS CURTIS C;SCHETTER AARON J
分类号 C12Q1/68;A01K67/027;A61K31/7105;A61K45/00;A61K48/00;A61P1/04;A61P35/00;C07K17/00;C12M1/00;C12N15/09;C12N15/113;C12Q1/02;G01N33/15;G01N33/50;G01N33/53;G01N33/574;G01N37/00 主分类号 C12Q1/68
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