| 摘要 |
PROBLEM TO BE SOLVED: To provide tests, diagnostic algorithms, and biomarkers for the diagnosis of intra-amniotic infection in a pregnant female mammalian subject.SOLUTION: A method for the diagnosis of intra-amniotic infection comprises; measuring in a sample of cervical-vaginal fluid obtained from a subject the levels of interleukin-6 (IL-6) and fetal fibronectin (fFN); and diagnosing the subject with intra-amniotic inflammation or intra-amniotic infection, if each of the levels of each of the proteins in the sample is determined to show a statistically significant difference relative to the corresponding levels of each of the proteins in the normal cervical-vaginal fluid, or is determined not to show a statistically significant difference relative to the corresponding levels of each of the proteins in the cervical-vaginal fluid known to be indicative of intra-amniotic inflammation or intra-amniotic infection. |
