| 主权项 |
1. 2-Substituted-6-biarylmethylamino-9-cyclopentyl-9H-purines of the general formula IwhereinX is CH or NR1 is selected from the group consisting of:
(4-aminocyclohexyl)amino, (2-aminocyclohexyl)amino, (3-aminocyclohexyl)amino, (4-hydroxycyclohexyl)amino, [(2R)-1-hydroxybutan-2-yl]amino, (2-hydroxy-2-methylpropyl)amino, (3-hydroxy-3-methylbutyl)amino, [(3S)-2-hydroxy-2,4-dimethylpent-3-yl]amino, piperazin-1-yl, 4-methylpiperazin-1-yl, morpholin-4-yl, [(1S)-1-(dimethylamino)-2-hydroxyethyl]amino, [(3R)-2-hydroxypent-3-yl]amino, (3-hydroxypropyl)amino, (2-aminoethyl)amino, (3-aminopropyl)amino, (2-aminopropyl)amino, 4-(aminomethyl)piperidin-1-yl, (piperidin-4-ylmethyl)amino, 4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl, 4-(2-hydroxyethyl)piperazin-1-ylandR2 is selected from the group consisting of
substituted phenyl, wherein the substituents are in any positions and are independently selected from the group consisting of OH, OCH3, NH2, Cl, Br, F, I, COOH, NO2, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl 3-furanyl, thien-2-yl, thien-3-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrrol-1-yl,and the pharmaceutically acceptable salts thereof, in particular salts with alkali metals, ammonium or amines, or addition salts with acids. |
