| 摘要 |
The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration. |
| 主权项 |
1. Method for producing a melanogenetic action in the hair and to promote its pigmentation, particularly pigmentation of the stem, comprising the step of administering to a subject in need thereof an effective dose of a compound of formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1—R,
H2N—(CH2)3—N1(R)—(CH2)4—NH2 (I) wherein R is a substituent that is bound to the secondary amine group of spermidine, chosen from saturated or unsaturated, linear or branched alkyl groups formed from 1 to 6 atoms of carbon, wherein one or more carbon atoms are optionally replaced by fluorine, namely methyl, ethyl, trifluoromethyl, trifluoroethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, ethylene, vinyl, propylene, butylene; aryl or aryl-alkyl groups, such as phenyl, naphthyl, benzyl, tolyl, wherein one or more carbon atoms are optionally replaced by fluorine, and wherein said aryl-alkyl groups include saturated or unsaturated, linear or branched alkyl groups formed by 1 to 6 atoms of carbon, wherein one or more carbon atoms are optionally replaced by fluorine, namely methyl, ethyl, trifluoromethyl, trifluoroethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, ethylene, vinyl, propylene, butylene; saturated or unsaturated cycloalkyl groups formed by 3 to 8 atoms of carbon that are optionally replaced by saturated or unsaturated, linear or branched alkyl groups formed by 1 to 6 atoms of carbon, wherein one or more carbon atoms are optionally replaced by fluorine, namely methyl, ethyl, trifluoromethyl, trifluoroethyl, propyl, isopropyl, butyl, isobutyl, pentyl, hexyl, ethylene, vinyl, propylene, butylene; or their pharmaceutically acceptable salt. |
