发明名称 |
FLUOROUS AFFINITY EXTRACTION FOR IONIC LIQUID-BASED SAMPLE PREPARATION |
摘要 |
A method for removing an ionic liquid from an aqueous sample is provided. In some embodiments, the method includes: (a) combining an aqueous sample including an ionic liquid with an ion exchanger composition including an ion exchanger counterion to produce a solution including a fluorous salt of the ionic liquid, where at least one of the ionic liquid and the ion exchanger counterion is fluorinated; (b) contacting the solution with a fluorous affinity material, thereby removing fluorous salt from the solution and producing an aqueous eluate; and (c) collecting the aqueous eluate. In certain embodiments, the method further includes: contacting a cell with an ionic liquid composition to lyse the cell and produce an aqueous sample; and contacting the aqueous sample with a reverse phase substrate, thereby adsorbing proteins and/or lipids of the cell on the substrate. Compositions, kits and systems for practicing the subject methods are also provided. |
申请公布号 |
US2015369711(A1) |
申请公布日期 |
2015.12.24 |
申请号 |
US201514724656 |
申请日期 |
2015.05.28 |
申请人 |
Agilent Technologies, Inc. |
发明人 |
Smart Brian Phillip;Bond-Watts Brooks;Apffel, Jr. James Alexander |
分类号 |
G01N1/34;B01D11/04 |
主分类号 |
G01N1/34 |
代理机构 |
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代理人 |
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主权项 |
1. A method for removing an ionic liquid from an aqueous sample, the method comprising:
(a) combining an aqueous sample comprising an ionic liquid with an ion exchanger composition comprising an ion exchanger counterion to produce a solution comprising a fluorous salt of the ionic liquid, wherein at least one of the ionic liquid and the ion exchanger counterion is fluorinated; (b) contacting the solution with a fluorous affinity material, thereby removing fluorous salt from the solution and producing an aqueous eluate; and (c) collecting the aqueous eluate. |
地址 |
Loveland CA US |