COMPOSITIONS OF PARTICULATE COFORMULATION

摘要

Embodiments of the invention provide a composition of a particulate coformulation which includes particles containing an active substance and an additive, wherein each particle contains a relative additive concentration increasing radially outwards from a particle center to a particle surface along a finite gradient. In one example, the particle surface is an additive-rich surface without a distinct physical boundary between the particle center and the particle surface. The relative additive concentration may have a continuous rate of change across the finite gradient. In some examples, an active substance:additive ratio of the particle surface is sufficiently low to form a protective surface layer around the active substance. Generally, the particle surface is free of the active substance.

主权项

1. A composition of a particulate coformulation, comprising:
an active substance and an additive, which is a solid dispersion of one component in the other, but which has a finite gradient in the relative additive concentration, which concentration increases radially outwards from the core to the surface of the particles, so that the particles have an additive-rich surface region but do not possess separate core and coating layers with a distinct physical boundary between them, wherein the coformulation is or comprises a pharmaceutical or nutraceutical agent or a foodstuff.