发明名称 |
Therapeutic agent comprising humanized anti-Epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma |
摘要 |
The present inventors succeeded in producing: an anti-Epiregulin antibody exhibiting a cross-species reactivity between a non-human animal crab-eating monkey and a human animal; an anti-Epiregulin antibody with suppressed chemical decomposition; an anti-Epiregulin antibody having a lowered isoelectric point; an anti-Epiregulin antibody having an elevated thermal denaturation midpoint temperature; and an anti-Epiregulin antibody having a reduced amount of aggregates, by appropriately substituting an amino acid residue in the variable region sequence of a humanized EP27 antibody that is capable of exhibiting a cytotoxic activity and neutralization activity on a cancer cell, said cancer cell expressing human Epiregulin, to thereby inhibit the proliferation of the cancer cell. Also, the present inventors succeeded in creating a therapeutic agent for non-small-cell lung carcinoma excluding adenocarcinoma, said therapeutic agent comprising one of the aforesaid antibodies as an active ingredient. |
申请公布号 |
AU2014299916(A1) |
申请公布日期 |
2015.12.24 |
申请号 |
AU20140299916 |
申请日期 |
2014.06.23 |
申请人 |
MIYAGI CANCER CENTER RESEARCH INSTITUTE;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
SUZUKI, MASAMI;KATO, ATSUHIKO;TAKEIRI, ETSUKO;HASHIMOTO, ERI;OUCHI, KAORI;SATOH, KENNICHI |
分类号 |
A61K39/395;A61P35/00;A61P43/00;C07K16/30;C07K16/46;C12N15/09;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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