发明名称 |
GLAUCOMA TREATMENT |
摘要 |
Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector. |
申请公布号 |
US2015366953(A1) |
申请公布日期 |
2015.12.24 |
申请号 |
US201414766854 |
申请日期 |
2014.02.12 |
申请人 |
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK ;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI |
发明人 |
DANIAS John;CANDIA Oscar A.;GEROMETTA Rosana |
分类号 |
A61K38/49;A61K31/366;A61K31/427;A61K31/09;A61K31/7088;C12N7/00 |
主分类号 |
A61K38/49 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treatment for an intraocular pressure (IOP)-associated condition in a subject, comprising administering to said subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. |
地址 |
Albany NY US |