发明名称 |
Methods for Treating Infections |
摘要 |
The present invention relates to methods for treating, preventing, or reducing the risk of microbial infections while minimizing adverse gastrointestinal effects using a two-stage dosing regimen comprising about 1 to about 7 days of intravenous administration followed by about 1 to about 14 days of oral administration of an antimicrobial agent. |
申请公布号 |
US2015366858(A1) |
申请公布日期 |
2015.12.24 |
申请号 |
US201514744671 |
申请日期 |
2015.06.19 |
申请人 |
Melinta Therapeutics, Inc. |
发明人 |
LI Danping;Hopkins Scott J.;Longcor Jarrod |
分类号 |
A61K31/4709;A61K9/46;A61K9/20;A61K9/48;A61K31/133;A61K9/00 |
主分类号 |
A61K31/4709 |
代理机构 |
|
代理人 |
|
主权项 |
1. A method for treating, preventing, or reducing the risk of a microbial infection in a patient in need thereof comprising:
(a) intravenously administering an intravenous formulation comprising a pharmaceutically effective amount of a quinolone carboxylic acid derivative or a pharmaceutically acceptable salt or ester thereof according to a schedule of once daily or twice daily from about 1 to about 7 days consecutively; and thereafter (b) orally administering an oral formulation comprising a pharmaceutically effective amount of said quinolone carboxylic acid derivative or said pharmaceutically acceptable salt or ester thereof according to a schedule of once daily or twice daily from about 1 to about 14 days consecutively; wherein said quinolone carboxylic acid derivative corresponds to the following compound (A) or a pharmaceutically acceptable salt or ester thereof. |
地址 |
New Haven CT US |