Derivative of Homoserine Lactone, and Preparation Method and Use Thereof

摘要

A derivative of homoserine lactone represented by formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.;

主权项

1. A derivative of homoserine lactone represented by formula I, a racemate or optical isomer, a pharmaceutically acceptable salt, a solvate or a hydrate thereof, wherein R is C1-12 linear or branched alkyl, or phenyl, said alkyl or phenyl is optionally mono-substituted or multi-substituted by a substituent selected from the group consisting of: phenyl, substituted or unsubstituted C1-5 linear or branched alkyl, halogen, cyano, trifluoromethyl, hydroxyl, nitro, substituted or unsubstituted C1-5 alkoxyl.