GENE DELIVERY SYSTEM CONTAINING RELAXIN GENE AND PHARMACEUTICAL COMPOSITION USING RELAXIN

摘要

The present invention relates to a novel gene delivery system and recombinant adenovirus including the relaxin-encoding sequence to enhance transduction efficiency of transgenes, a pharmaceutical anti-tumor composition including the recombinant adenovirus, a pharmaceutical composition having improved tissue penetration potency and a pharmaceutical composition for treating a disease or disorder associated with accumulation of excess extracellular matrix.

主权项

1. A method for enhancing the efficiency of transduction of a recombinant adenovirus into a target cell, comprising:
preparing the recombinant adenovirus comprising a promoter-nucleotide sequence of interest and a promoter-relaxin-encoding nucleotide sequence-polyadenlyation sequence; and infecting the target cell with the prepared recombinant adenovirus, wherein a relaxin protein expressed in the infected target cell enhances the efficiency of transduction of the prepared recombinant adenovirus which is not yet transduced into the target cell, and no use of a proteasome inhibitor is involved in a process of the method.