COMBINATION OF GERANYLGERANYLACETONE AND IBUDILAST AND METHODS OF USING SAME

摘要

The present invention relates generally to methods for treating progressive neurodegenerative diseases, including their progressive forms. In particular, the present invention pertains to methods of treating or preventing progressive neurodegenerative diseases and its associated symptoms by administration of a combination of geranylgeranylacetone (teprenone) and ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine), or pharmaceutically acceptable salts thereof.

主权项

1. A method of alleviating negative effects of a neurodegenerative disease or disorder in a human patient suffering therefrom, comprising administering to a patient in need thereof:
(a) a therapeutically effective amount of ibudilast or a pharmaceutically acceptable salt thereof, and (b) a therapeutically effective amount of geranylgeranylacetone (GGA) or a pharmaceutically acceptable salt thereof.