| 发明名称 |
CANCER THERAPY USING miRNAs |
| 摘要 |
The present invention relates generally to methods and compositions for the treatment of cancers expressing the type 1 insulin-like growth factor receptor (IGF1R) or a constituent of an IGF1R signaling pathway, in particular melanoma, using the microRNA miR-7-5p. Also provided are methods for increasing the sensitivity of such cancers to therapeutic agents. |
| 申请公布号 |
US2015366895(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201314436638 |
申请日期 |
2013.10.18 |
| 申请人 |
THE UNIVERSITY OF WESTERN AUSTRALIA |
发明人 |
LEEDMAN Peter Jeffery;GILES Keith Michael;BROWN Ann Mary |
| 分类号 |
A61K31/7105;A61K31/365;A61K31/495;A61K31/437 |
主分类号 |
A61K31/7105 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A synergistic composition for the treatment of a cancer or tumour expressing IGF1R or a constituent of an IGF1R signaling pathway, the composition comprising a miR-7-5p miRNA, a precursor or variant thereof or a miRNA comprising a seed region comprising the sequence GGAAGA, and at least one of a BRAF inhibitor, an IGF1R inhibitor and a DNA alkylating chemotherapeutic agent. |
| 地址 |
Western Australia AU |
