| 发明名称 |
NON-HUMAN ANIMALS HAVING A HUMANIZED PROGRAMMED CELL DEATH 1 GENE |
| 摘要 |
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that said non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion). |
| 申请公布号 |
US2015366174(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201514744592 |
申请日期 |
2015.06.19 |
| 申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
BUROVA Elena;MUJICA Alexander O.;LAI Ka-Man Venus;MURPHY Andrew J. |
| 分类号 |
A01K67/027;C07K16/28;G01N33/50;C07K14/705;A61K49/00;C12Q1/68 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A rodent that expresses a PD-1 polypeptide, which PD-1 polypeptide comprises a human sequence and an endogenous sequence. |
| 地址 |
Tarrytown NY US |
