PEPTIDE INHIBITOR OF NOX1 NADPH OXIDASE

摘要

An isolated peptide or fusion having the peptide useful to interfere with the phosphorylation of Nox1, block or inhibit binding of NoxA1 activation domain (AD) to Nox1, and/or prevent or inhibit assembly of the p47phox/NoxA1 complex with Nox1, or a vector encoding the peptide or fusion thereof, and methods of using the peptide, fusion or vector are provided.

主权项

1. An isolated peptide or fusion protein comprising the peptide, wherein the peptide has formula (I):(SEQ ID NO: 11)Z1-X1-X2-X1-X3-X1-X1-X2-Y-F-Z1 wherein each X1 is independently K, N, Q, or H; wherein each X2 is independently L, I, A, O or V; wherein X3 is T, S, Y, D, or E; and wherein each Z1 is independently absent, or is 1 to 50 amino acids in length.