INHIBITORS OF HEMEPROTEIN-CATALYZED LIPID PEROXIDATION

摘要

Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.

主权项

1. A compound of the following formula:wherein X is C, O, or NR2; R1 is independent and selected from hydrogen, alkyl, C3-10 cycloalkyl, aryl, benzyl, heteroaryl, halogen, CN, CF3, CO, CO-alkyl; R2 is selected from hydrogen, alkyl, C3-10 cycloalkyl, aryl, benzyl, heteroaryl, halogen, CN, CF3, CO, CO-alkyl; or a pharmaceutically acceptable salt thereof.