| 摘要 |
The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). The compounds are considered useful for the treatment of diseases treatment of a neurodegenerative disease, psychiatric disease, motorneuron disease, peripheral neuropathies, pain, neuroinflammation or atherosclerosis such as Alzheimer's disease and Parkinson's disease.; |
| 主权项 |
1. A compound of Formula A wherein R1 represents H or F, R2 represents halogen, C1-C6 alkyl, C2-C6 alkenyl or C1-C6 halogenated alkyl, R3 represents halogen, H, C1-C6 alkyl or C1-C6 halogenated alkyl, L is a direct bond or represents CH2, R4 represents a 5-6 membered heteroaromatic monocyclic ring with 1 or 2 heteroatom(s) or a 8-10 membered bicyclic heterocyclic ring with 1 or 2 heteroatom(s), said heteroaromatic or bicylic rings may be substituted with C≡N, 1 or 2 C1-C3 alkyl, 1 or 2 halogenated alkyl, 1 or 2 C1-C3 alkoxy or 1 or 2 halogen(s), and pharmaceutically acceptable salts or prodrugs thereof, with the proviso that the compound is not 5-methyl-2-[[(4-methyl-2-thiazolyl)amino]carbonyl]. |
