| 发明名称 |
MODIFIED CANINE LEPTIN POLYPEPTIDES |
| 摘要 |
Modified canine leptin polypeptides and formulations and uses thereof, are provided including polyethylene glycol (PEG) modified canine leptin polypeptides, wherein the PEG moiety is covalently attached to a para-acetyl-phenylalanine (pAF) residue of the polypeptide, and related compositions and methods useful in treating companion animal obesity and other leptin-related disorders. |
| 申请公布号 |
US2015366983(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201414765931 |
申请日期 |
2014.03.12 |
| 申请人 |
ELI LILLY & COMPANY ;AMBRX, INC. |
发明人 |
BLEDSOE Michael;CANNING Peter Connor;DEGUZMAN Michael;KNUDSEN Nick;VALENTA Ianina |
| 分类号 |
A61K47/48;A61K38/22 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound comprising a polypeptide of SEQ ID NO: 1 and a polyethylene glycol (PEG) moiety, wherein the PEG moiety is covalently attached to a para-acetyl-phenylalanine (pAF) residue of the polypeptide of SEQ ID NO: 1. |
| 地址 |
Indianapolis IN US |
