RESPIRATORY SYNCYTIAL VIRUS F PROTIEN EPITOPES

摘要

Respiratory Syncytial Virus is a common cold virus belonging to the family of paramyxovirus. RSV is virulent, easily transmissible and the most common cause of lower respiratory tract disease in children of less than 2 years of age. Up to 98% of children attending day care will be infected in a single RSV season. Between 0.5% and 3.2% of children with RSV infection require hospitalization. Approximately 90,000 hospital admissions and 4500 deaths per year were reported in United States. Major risk factors for hospitalization due to RSV are premature birth, chronic lung disease, congenital heart disease, compromised immunity, and age younger than 6 weeks in otherwise healthy children.

主权项

1. A conformational epitope on the surface of a respiratory syncytial virus fusion (RSV F) protein, comprising at least 6 amino acids within amino acids 1 to 34 of SEQ ID NO:7 or amino acids 1 to 34 of SEQ ID NO:9, wherein an RSV F protein comprising the epitope can be specifically bound by monoclonal antibody D25 or an antigen-binding fragment, variant, analog or derivative thereof, provided that the RSV F protein is in pre-fusion conformation.