Computer Aided Drug Resistance Calculator Calculating Drug Resistance Using Amprenavir As A Case Study

摘要

Signal Processing-based Computer-Aided Drug Resistance Calculator (CARDC) has been proposed [14]. The result of the drug resistances obtained then demonstrated very small margin. It was noted that more than one amino acids parameter is engaged in one mutation. It became necessary to further apply CARDC on studies which have information on both mutations in the target protein and the amino acids parameters involved. Amprenavir, an anti-HIV/AIDS that has been approved by FDA has been studied and information regarding mutations and amino acids parameters are available [12]. CARDC is therefore applied on these mutations and amino acids parameters presented.