发明名称 |
COMPOSITIONS AND METHODS FOR WEIGHT LOSS IN AT RISK PATIENT POPULATIONS |
摘要 |
The present disclosure relates to compositions, kits, uses, systems and methods related to naltrexone plus bupropion for treating an overweight or obese subject at increased risk of adverse cardiovascular outcomes. Preferably, the subject has had type-two diabetes for a period of less than 6 years or is a current smoker, optionally that does not have type-two diabetes. |
申请公布号 |
US2015366860(A1) |
申请公布日期 |
2015.12.24 |
申请号 |
US201514839792 |
申请日期 |
2015.08.28 |
申请人 |
Orexigen Therapeutics, Inc. |
发明人 |
Klassen Preston;Taylor Kristin |
分类号 |
A61K31/485;A61K31/137 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a subject for overweight or obesity, comprising:
selecting an overweight or obese subject at increased risk of adverse cardiovascular outcomes that has had type-two diabetes for a period of less than 6 years; and treating the subject for overweight or obesity by administering to the subject a daily dose of 32 mg of sustained release naltrexone, or a pharmaceutically acceptable salt thereof and 360 mg bupropion, or a pharmaceutically acceptable salt thereof, for a period of at least 12 weeks. |
地址 |
La Jolla CA US |