| 发明名称 |
NOVEL APPROACH FOR SYNTHESIS OF CATECHINS |
| 摘要 |
A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+and/or−) epicatechin echm and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin. |
| 申请公布号 |
US2015368223(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201414763018 |
申请日期 |
2014.01.27 |
| 申请人 |
SPHAERA PHARMA PVT. LTD. |
发明人 |
Dugar Sundeep;Mahajan Dinesh;Rai Kumar Santosh;Tripathi Vinayak;Patil Ishwar Rakesh |
| 分类号 |
C07D311/62;C07F7/18;C07D311/30 |
主分类号 |
C07D311/62 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+and/or−) epicatechin and its intermediates, comprising the steps of:
I. obtaining penta-protected quercetin; II. reducing the penta-protected quercetin obtained from step (i); III. optionally deprotecting the compound of step (ii); IV. reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; V. deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin. VI. Optionally simultaneously deprotecting and hydrogenation of the compound obtained from step (ii) to obtain racemic epicatechin. |
| 地址 |
Imt Manesar, Haryana IN |
