发明名称 |
METHOD FOR TREATING CANCER USING A COMBINATION OF CHK1 AND ATR INHIBITORS |
摘要 |
The present invention relates to methods of treating cancer in a patient by administering a compound useful as an inhibitor of ATR protein kinase in combination with a compound useful as an inhibitor of Chkl protein kinase. The aforementioned combination displays a surprising synergistic effect in treating cancer despite the targeted protein kinases being within the same biological pathway. Moreover, the present invention also relates to methods of treating cancer by administering a compound useful as an inhibitor of ATR protein kinase; administering a compound useful as an inhibitor of Chkl protein kinase; as well as administering a DNA damaging agent to a patient. The compounds utilized in this invention are represented by formula (I) and formula (II): wherein the variables are as defined herein. |
申请公布号 |
WO2015195740(A1) |
申请公布日期 |
2015.12.23 |
申请号 |
WO2015US36137 |
申请日期 |
2015.06.17 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
HELLEDAY, THOMAS;SANJIV, KUMAR |
分类号 |
A61K45/00;A61P35/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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