发明名称 |
TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES |
摘要 |
The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided. |
申请公布号 |
WO2015193484(A1) |
申请公布日期 |
2015.12.23 |
申请号 |
WO2015EP63838 |
申请日期 |
2015.06.19 |
申请人 |
DREXEL UNIVERSITY;BARUCH S. BLUMBERG INSTITUTE;F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC. |
发明人 |
GUO, HAITAO;CAI, DAWAI;CUCONATI, ANDREA;JI, CHANGHUA |
分类号 |
C07K14/005;G01N33/576 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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