发明名称 |
CARDIOVASCULAR DISEASE PRIMARY PREVENTION AGENT FOR PATIENTS HAVING HIGH BLOOD LEVELS OF HIGH-SENSITIVITY C-REACTIVE PROTEIN |
摘要 |
The present invention provides the following: a cardiovascular disease primary prevention agent, which comprises as the active ingredient at least one selected from the group consisting of EPA, salts thereof, and esters thereof and is for lowering the risk of cardiovascular disease by administration to subjects having a blood (serum or plasma) hs-CRP level of 1.0 mg/L or higher in spite of no history of cardiovascular disease; a combination marker comprising the blood hs-CRP value and serum EPA/AA ratio for evaluating the primary risk of cardiovascular disease in subjects having no history of cardiovascular disease; and a method for extracting subjects with high risk of cardiovascular disease and/or a method for preventing cardiovascular disease. |
申请公布号 |
EP2851069(A4) |
申请公布日期 |
2015.12.23 |
申请号 |
EP20130790182 |
申请日期 |
2013.05.14 |
申请人 |
MOCHIDA PHARMACEUTICAL CO., LTD.;KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION |
发明人 |
KIYOHARA YUTAKA;NINOMIYA TOSHIHARU;YANO TAKASHI |
分类号 |
A61K31/202;A61K31/232;A61P7/12;A61P9/00;A61P9/10;G01N30/88;G01N33/50;G01N33/53 |
主分类号 |
A61K31/202 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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