发明名称 |
ZALEPLON GASTRORETENTIVE DRUG DELIVERY SYSTEM |
摘要 |
A biodegradable, multi-layered controlled release gastroretentive baclofen or R-baclofen dosage form which is optionally divided into a first dosage of baclofen or R-baclofen for immediate release and a second dosage of baclofen or R-baclofen for controlled release in the stomach and gastrointestinal tract of a patient, folded into a capsule which disintegrates upon contact with gastric juice and the dosage form unfolds rapidly upon contact with gastric juice. The biodegradable, multi-layered gastroretentive dosage forms of the invention provide fast onset of baclofen or R-baclofen activity with prolonged absorption and minimal undesirable side effects. |
申请公布号 |
EP2378883(B1) |
申请公布日期 |
2015.12.23 |
申请号 |
EP20090830077 |
申请日期 |
2009.10.19 |
申请人 |
INTEC PHARMA LTD. |
发明人 |
MASRI, SUHER;MOOR, EYTAN;KIRMAYER, DAVID;KLUEV, ELENA;CARNI, GIORA;NAVON, NADAV |
分类号 |
A61K9/48;A61K9/70;A61K31/195 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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