| 摘要 |
The present invention provides methods for controlling developmental potential of a human stem cell via gene editing of a lineage-specification gene in a human stem cell genome, wherein the gene editing produces a human stem cell with limited capability of differentiating into the cell lineage for which the lineage-specification gene is specific. The invention also provides recombinant human stem cells made using the methods of the invention, and uses for such recombinant human stem cells. |
