发明名称 |
THERAPEUTIC COMBINATIONS OF A BTK INHIBITOR, A PI3K INHIBITOR AND/OR A JAK-2 INHIBITOR |
摘要 |
Therapeutic combinations of a Janus kinase-2 (JAK-2) inhibitor, a Bruton's tyrosine kinase (BTK) inhibitor, and/or a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the γ- and δ-isoforms and selective for both γ- and δ-isoforms, are described. In some embodiments, the invention provides pharmaceutical compositions comprising combinations of (1) a ΡΙ3Κ-δ inhibitor and a BTK inhibitor, (2) a JAK-2 inhibitor and a BTK inhibitor, or (3) a JAK-2 inhibitor, ΡΙ3Κ-δ inhibitor, and BTK inhibitor, and methods of using the pharmaceutical compositions for treating a disease, in particular a cancer. |
申请公布号 |
WO2015193740(A2) |
申请公布日期 |
2015.12.23 |
申请号 |
WO2015IB01811 |
申请日期 |
2015.06.17 |
申请人 |
ACERTA PHARMA B.V. |
发明人 |
HAMDY, AHMED;ROTHBAUM, WAYNE;IZUMI, RAQUEL;LANNUTTI, BRIAN;COVEY, TODD;ULRICH, ROGER;JOHNSON, DAVE;BARF, TJEERD;KAPTEIN, ALLARD |
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