发明名称 |
PEPTIDE CONTAINING PORPHYRIN LIPID NANOVESICLES |
摘要 |
There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35nm in diameter or less. |
申请公布号 |
WO2015192215(A1) |
申请公布日期 |
2015.12.23 |
申请号 |
WO2015CA00397 |
申请日期 |
2015.06.18 |
申请人 |
UNIVERSITY HEALTH NETWORK |
发明人 |
CHEN, JUAN;ZHENG, GANG;CUI, LIYANG |
分类号 |
A61K9/133;A61K9/51;A61K41/00;A61K47/24;A61K47/42;A61K49/00;A61P35/00 |
主分类号 |
A61K9/133 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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