发明名称 |
Deuterium-enriched 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide |
摘要 |
Deuterium-enriched 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[(4-trifluoromethyl) -phenyl]-1,2-dihydroquinoline-3-carboxamide, having a deuterium enrichment in the amide-N methyl group of at least 70%; or a salt thereof with a pharmaceutically acceptable organic or inorganic cation; and a method of preparing said compounds. The compounds are useful in therapy, e.g. for the treatment of a malignant hyperproliferative disorder or an autoimmune disease. |
申请公布号 |
US9216956(B2) |
申请公布日期 |
2015.12.22 |
申请号 |
US201214125666 |
申请日期 |
2012.06.20 |
申请人 |
ACTIVE BIOTECH AB |
发明人 |
Svensson Leif |
分类号 |
C07D215/00;C07D215/56;A61K31/4704 |
主分类号 |
C07D215/00 |
代理机构 |
Young & Thompson |
代理人 |
Young & Thompson |
主权项 |
1. A method of preparing a deuterium-enriched 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[(4-trifluoromethyl)phenyl]-1,2-dihydroquinoline-3-carboxamide, or a pharmaceutically acceptable salt thereof, comprising
reacting a C1-C4 alkyl ester of 4-hydroxy-5-methoxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid with deuterium-enriched N-methyl-p-trifluoromethylaniline, wherein the N-methyl group has a deuterium enrichment of at least 70%. |
地址 |
Lund SE |