| 发明名称 |
Aptamer drug for detoxification of <i>Staphylococcus aureus </i>alpha-toxin |
| 摘要 |
Aptamers and methods of use thereof are presented for the treatment or diagnosis of Staphylococcus aureus infection. The aptamers binds to and capable of neutralization of Staphylococcus aureus alpha-toxin. |
| 申请公布号 |
US9217134(B1) |
申请公布日期 |
2015.12.22 |
| 申请号 |
US201414470506 |
申请日期 |
2014.08.27 |
| 申请人 |
The United States of America as Represented by the Secretary of the Navy |
发明人 |
Vivekananda Jeevalatha;Millenbaugh Nancy J. |
| 分类号 |
C12N15/115;C12Q1/68;C12N1/20;G01N33/50 |
主分类号 |
C12N15/115 |
| 代理机构 |
|
代理人 |
Yang Ning;Churillo Albert M.;Tso Diane P. |
| 主权项 |
1. An aptamer that binds to Staphylococcus aureus alpha toxin and reduces its cytolytic and cytotoxic effects, wherein the aptamer comprises a nucleotide sequence selected from the group consisting of SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12. |
| 地址 |
Washington DC US |
