| 主权项 |
1. A compound described by formula (la):wherein,
R1 is O(CH2CH2O)nCH2CH2X1, O(CH2CH2CH2O)nCH2CH2X1, NHCH2CH2X2, NH(CH2CH2O)mCH2CH2X2, NH(CH2CH2CH2O)mCH2CH2X2, NH(CH2CH2O)pCH2CH2X3, NH(CH2CH2CH2O)pCH2CH2X3, NH[CH2(CH2)aO]bCH{CH2[OCH2(CH2)c]dX5}2, O[CH2(CH2)aO]bCH{CH2[OCH2(CH2)c]dX5}2, NH(CH2CH2NH)rCH2CH2X5, NHCH2(CH2)qX6, or OCH2(CH2)qX6; RT is n-pentyl, sec-pentyl, or iso-pentyl; X1 is NH2, NHRA1, NRA1RA2, or NRA1RA2RA3; X2 is OH or ORB1; X3 is NH2, NHRC1, NRC1RC2, or NRC1RC2RC3; each X5 is, independently, selected from OH, ORE1, NH2, NHRE1, NRE1RE2, or NRE1RE2RE3; X6 is selected from NRF1RF2RF3; a is an integer from 1 to 2; b is an integer from 0 to 3; c is an integer from 1 to 2; d is an integer from 0 to 3; n is an integer from 1 to 5; m is an integer from 1 to 5; p is an integer from 1 to 5; r is an integer from 1 to 5; q is an integer from 1 to 3; and each of RA1, RA2, RA3, RB1, RC1, RC2,RC3RE1, RE2, RE3, RF1, RF2, and RF3 is, independently, selected from CH3, CH2CH3, CH2CH2CH3, or CH(CH3)2, or a pharmaceutically acceptable salt thereof, wherein the compound is not compound 1 or a pharmaceutically acceptable salt thereof. |
