| 发明名称 | Modified polynucleotides encoding granulysin | ||
| 摘要 | The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules. | ||
| 申请公布号 | US9216205(B2) | 申请公布日期 | 2015.12.22 |
| 申请号 | US201314107053 | 申请日期 | 2013.12.16 |
| 申请人 | Moderna Therapeutics, Inc. | 发明人 | Chakraborty Tirtha;de Fougerolles Antonin |
| 分类号 | C12N15/85;A61K38/17;C07K14/47;C07K14/62;A61K48/00;A61K31/7115;C12N9/88;A61K9/127;C12N15/11;C07K14/705;C07K14/505;C07K14/535;C12N9/64;C12N9/10;C12N9/00;C12N9/42;C12N15/87;C12P13/04;A61K38/45;C07K14/005;C12N9/16;C12N9/24;C12N15/52;C07K14/435;C12P21/00;C07K14/485;A61K38/00 | 主分类号 | C12N15/85 |
| 代理机构 | DT Ward, P.C. | 代理人 | DT Ward, P.C. ;Ward Donna T.;Bryan Jennifer F. |
| 主权项 | 1. An mRNA encoding SEQ ID NO: 6373, wherein said mRNA comprises a coding region, said coding region having greater than 80% identity to SEQ ID NO: 32794. | ||
| 地址 | Cambridge MA US | ||