Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices

摘要

System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.

主权项

1. A method for monitoring a parameter of one or more samples positioned in an incubator, comprising:
(a) irradiating a fluorescent seminaphthofluorescein species having a first emission intensity at a first emission wavelength and a second emission intensity at a second emission wavelength, each emission intensity dependent on a parameter, with excitation light emanating from a probe physically isolated from the fluorescent species to provide first and second emission intensities, wherein the fluorescent species is in liquid communication with a sample contained in a vessel in an incubator; (b) measuring the first and second emission intensities to determine a first parameter reading of the sample; and (c) repeating step (a) after a pre-determined time and measuring the first and second emission intensities to determine a second parameter reading of the sample.