| 发明名称 |
Monoclonal antibodies against Glypican-3 |
| 摘要 |
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed. |
| 申请公布号 |
US9217033(B2) |
申请公布日期 |
2015.12.22 |
| 申请号 |
US201414176790 |
申请日期 |
2014.02.10 |
| 申请人 |
E. R. SQUIBB & SONS, L.L.C. |
发明人 |
Terrett Jonathan Alexander;Lu Li-Sheng;Huang Haichun;Yao Dapeng;Pan Chin;LeBlanc Heidi N.;Sproul Tim W.;Yamanaka Mark |
| 分类号 |
C07K16/28;C07K16/30;A61K39/00 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
Chao Yuan;Guo Zhongmin |
| 主权项 |
1. An isolated nucleic acid molecule encoding;
(a) a heavy chain of an anti-Glypican-3 antibody, or antigen-binding portion thereof, wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 19; or (b) a light chain of an anti-Glypican-3 antibody, or antigen-binding portion thereof, wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO: 22. |
| 地址 |
Princeton NJ US |
